Novel substituted phenoxyalkyl pyridinium oximes enhance survival and attenuate seizure-like behavior of rats receiving lethal levels of nerve agent surrogates

Author:

Chambers Janice E.ORCID,Meek Edward C.,Bennett Joshua P.,Bennett W.Shane,Chambers Howard W.,Leach C. Andrew,Pringle Ronald B.,Wills Robert W.

Publisher

Elsevier BV

Subject

Toxicology

Reference27 articles.

1. Testing of novel brain-penetrating oxime reactivators of acetylcholinesterase inhibited by nerve agent surrogates;Chambers;Chem. Biol. Interact.,2013

2. Effects of acute paraoxon and atropine exposures on retention of shuttle avoidance behavior in rats;Chambers;Neurosci. Res. Comm.,1988

3. Efficacy of pro-PAM (n-methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride) as a prophylaxis against organophosphate poisoning;Clement;Toxicol. Appl. Pharmacol.,1979

4. The acetylcholinesterase oxime reactivator HI-6 in man: pharmacokinetics and tolerability in combination with atropine;Clement;Biopharm. Drug Dispos.,1995

5. Pro-2-PAM therapy for central and peripheral cholinesterases;Demar;Chem. Biol. Interact.,2010

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