Testing of novel brain-penetrating oxime reactivators of acetylcholinesterase inhibited by nerve agent surrogates-Reference-Cited by-同舟云学术

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Testing of novel brain-penetrating oxime reactivators of acetylcholinesterase inhibited by nerve agent surrogates

Published:2013-03 Issue:1 Volume:203 Page:135-138
ISSN:0009-2797
Container-title:Chemico-Biological Interactions
language:en
Short-container-title:Chemico-Biological Interactions

Author:

Chambers Janice E.,Chambers Howard W.,Meek Edward C.,Pringle Ronald B.

Funder

Defense Threat Reduction Agency

Henry M. Jackson Foundation

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference9 articles.

1. Toxic effects of pesticides;Ecobichon,2001

2. Efficacy of pro-PAM (n-methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride) as a prophylaxis against organophosphate poisoning;Clement;Toxicol. Appl. Pharmcol.,1979

3. Pralidoxime iodide (2-PAM) penetrates across the blood–brain barrier;Sakurada;Neurochem. Res.,2003

4. New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications;Kuca;Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub.,2005

5. Reactivation of brain acetylcholinesterase by monoisonitrosoacetone increases the therapeutic efficacy against nerve agents in guinea pigs;Skovira;Chem. Biol. Interact.,2010

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1. Reactivation by novel pyridinium oximes of rat serum and skeletal muscle acetylcholinesterase inhibited by organophosphates;Journal of Biochemical and Molecular Toxicology;2024-07

2. Discovery of (E)-2-(hydroxyimino)-N-(2 ((4methylpentyl)amino)ethyl)acetamide (KR-27425) as a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase;Bioorganic & Medicinal Chemistry Letters;2023-11

3. The in silico identification of novel broad-spectrum antidotes for poisoning by organophosphate anticholinesterases;Journal of Computer-Aided Molecular Design;2023-10-05

4. Improved chemical synthesis, identification and evaluation of prospective centrally active oxime antidotes for the treatment of nerve agent exposure;Tetrahedron;2023-09

5. Synthesis of Novel Oxime and Benzofuran Chemical Frameworks Possessing Potent Anticholinesterase Activity: A SAR Study Related to Alzheimer Disease;ChemistrySelect;2023-08-10

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