Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice

Author:

Kassa JiriORCID,Timperley Christopher M.,Bird Mike,Williams Rebecca L.,Green A. Christopher,Tattersall John E.H.

Funder

Ministry of Defence of the Czech Republic called “Long-term organization development plan – Medical Aspects of Weapons of Mass Destruction’’

Publisher

Elsevier BV

Subject

Toxicology

Reference36 articles.

1. Acetylcholinesterase reactivators modify the functional properties of the nicotinic acetylcholine receptor ion channel;Alkondon;J. Pharmacol. Exp. Ther.,1988

2. Unequal efficacy of pyridinium oximes in acute organophosphate poisoning;Antonijevic;Clin. Med. Res.,2007

3. Organophosphate/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis and treatment;Bajgar;Adv. Clin. Chem.,2004

4. Direct reaction of oximes with sarin, soman, or tabun in vitro;Becker;Arch. Toxicol.,1997

5. Acetylcholinesterase inhibitors: pharmacology and toxicology;Colovic;Curr. Neuropharmacol.,2013

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