Chemoselective Hydrogenation of 6‐Alkynyl‐3‐fluoro‐2‐pyridinaldoximes: Access to First‐in‐Class 6‐Alkyl‐3‐Fluoro‐2‐pyridinaldoxime Scaffolds as New Reactivators of Sarin‐Inhibited Human Acetylcholinesterase with Increased Blood–Brain Barrier Permeability-Reference-Cited by-同舟云学术

Chemoselective Hydrogenation of 6‐Alkynyl‐3‐fluoro‐2‐pyridinaldoximes: Access to First‐in‐Class 6‐Alkyl‐3‐Fluoro‐2‐pyridinaldoxime Scaffolds as New Reactivators of Sarin‐Inhibited Human Acetylcholinesterase with Increased Blood–Brain Barrier Permeability

Published:2020-10-20 Issue:65 Volume:26 Page:15035-15044
ISSN:0947-6539
Container-title:Chemistry – A European Journal
language:en
Short-container-title:Chem. Eur. J.

Author:

Yerri Jagadeesh¹,Dias José²,Nimmakayala Mallikajurna Reddy¹,Razafindrainibe Franck¹,Courageux Charlotte²,Gastellier Anne‐Julie²,Jegoux Johanne²,Coisne Caroline³,Landry Christophe³,Gosselet Fabien³,Hachani Johan³,Goossens Jean‐François⁴,Dehouck Marie‐Pierre³,Nachon Florian²,Baati Rachid¹^ORCID

Affiliation:

1. ICPEES UMR CNRS 7515 Institut de Chimie des Procédés, pour l'Energie, l'Environnement, et la Santé 25 Rue Becquerel 67087 Strasbourg France

2. Département de Toxicologie et Risques Chimiques Institut de Recherche Biomédicale des Armées 91220 Brétigny-sur-Orge France

3. UR 2465 Laboratoire de la Barrière Hémato-Encéphalique (LBHE) Université d'Artois (UArtois) 62307 Lens France

4. ULR 7365—GRITA—Groupe de Recherche sur les Formes, Injectables et Technologies Associées University of Lille 59000 Lille France

Funder

Agence Nationale de la Recherche

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/chem.202002012

Reference80 articles.

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3. The Experimental Oxime K027—A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime

4. The global burden of fatal self-poisoning with pesticides 2006-15: Systematic review

5. Classification and Uses of Organophosphates and Carbamates

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