SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

Author:

Hou Yixuan J.,Okuda Kenichi,Edwards Caitlin E.,Martinez David R.,Asakura Takanori,Dinnon Kenneth H.,Kato Takafumi,Lee Rhianna E.,Yount Boyd L.,Mascenik Teresa M.,Chen Gang,Olivier Kenneth N.,Ghio Andrew,Tse Longping V.,Leist Sarah R.,Gralinski Lisa E.,Schäfer Alexandra,Dang Hong,Gilmore Rodney,Nakano Satoko,Sun Ling,Fulcher M. Leslie,Livraghi-Butrico Alessandra,Nicely Nathan I.,Cameron Mark,Cameron Cheryl,Kelvin David J.,de Silva Aravinda,Margolis David M.,Markmann Alena,Bartelt Luther,Zumwalt Ross,Martinez Fernando J.,Salvatore Steven P.,Borczuk Alain,Tata Purushothama R.,Sontake Vishwaraj,Kimple Adam,Jaspers Ilona,O’Neal Wanda K.,Randell Scott H.,Boucher Richard C.,Baric Ralph S.ORCID

Funder

National Allergy and Infectious Disease

National Heart, Lung, and Blood Institute

Cystic Fibrosis Foundation

Cystic Fibrosis Research Incorporation

NIH NIAID

Burroughs Wellcome Fund Postdoctoral Enrichment Program Award

American Lung Association

National Center for Advancing Translational Sciences

NHLBI

NIH

NCI Center Core Support Grant

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference107 articles.

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2. Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue;Aguiar;bioRxiv,2020

3. Engineering the largest RNA virus genome as an infectious bacterial artificial chromosome;Almazán;Proc. Natl. Acad. Sci. USA,2000

4. A clinical consideration of abscesses and cavities of the lung;Amberson;Bull. Johns Hopkins Hosp.,1954

5. The proximal origin of SARS-CoV-2;Andersen;Nat. Med.,2020

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