Killer fatigue: Transition to NK-cell-like phenotype is a signature of CAR-T cell exhaustion

Author:

Hong Mihe,Chen Yvonne Y.ORCID

Funder

Cancer Research Institute

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference10 articles.

1. Mechanisms of CAR T cell dysfunction and identification of transcription factors to improve antitumor function;Good;Cell,2021

2. Engineering CAR-T Cells for Next-Generation Cancer Therapy;Hong;Cancer Cell,2020

3. Navigating CAR-T cells through the solid-tumour microenvironment;Hou;Nat. Rev. Drug Discov.,2021

4. A genome-wide regulatory network identifies key transcription factors for memory CD8+ T-cell development;Hu;Nat. Commun.,2013

5. Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells;Ji;Nat. Immunol.,2011

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