Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity-Reference-Cited by-同舟云学术

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Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity

Published:2019-04 Issue:3 Volume:177 Page:597-607.e9
ISSN:0092-8674
Container-title:Cell
language:en
Short-container-title:Cell

Author:

Lotta Luca A.,Mokrosiński Jacek,Mendes de Oliveira Edson,Li Chen,Sharp Stephen J.,Luan Jian’an,Brouwers Bas,Ayinampudi Vikram,Bowker Nicholas,Kerrison Nicola,Kaimakis Vasileios,Hoult Diana,Stewart Isobel D.,Wheeler Eleanor,Day Felix R.,Perry John R.B.,Langenberg Claudia,Wareham Nicholas J.,Farooqi I. Sadaf

Funder

Medical Research Council

NIHR

EU FP6

Wellcome Trust

Botnar Foundation

Bernard Wolfe Health Neuroscience Endowment

MRC

MRL

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference70 articles.

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2. Mendelian randomization analysis with multiple genetic variants using summarized data;Burgess;Genet. Epidemiol.,2013

3. The UK Biobank resource with deep phenotyping and genomic data;Bycroft;Nature,2018

4. RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals;Chen;J. Clin. Endocrinol. Metab.,2015

5. Genetic variants associated with Lp(a) lipoprotein level and coronary disease;Clarke;N. Engl. J. Med.,2009

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