Reducing risk, improving outcomes: Bioengineering less immunogenic protein therapeutics

Author:

De Groot Anne S.,Martin William

Publisher

Elsevier BV

Subject

Immunology,Immunology and Allergy

Reference51 articles.

1. Committee for Medicinal Products for Human Use (CHMP). Guideline on immunogenicity assessment of biotechnology-derived therapeutic proteins, Doc. Ref. EMEA/CHMP/BMWP/14327/2006, London, 2007

2. Recommendations for the design and optimization of immunoassays used in the detection of host antibodies against biotechnology products;Mire-Sluis;J. Immunol. Methods,2004

3. Immunogenicity of protein therapeutics;De Groot;Trends Immunol.,2007

4. Clinical validation of the “in silico” prediction of immunogenicity of a human recombinant therapeutic protein;Koren;Clin. Immunol.,2007

5. Immunogenicity of protein therapeutics and the interplay between tolerance and antibody responses;Barbosa;Drug Discov. Today,2007

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