Statistical experimental design and partial least squares regression analysis of biofluid metabonomic NMR and clinical chemistry data for screening of adverse drug effects

Author:

Antti Henrik,Ebbels Timothy M.D.,Keun Hector C.,Bollard Mary E.,Beckonert Olaf,Lindon John C.,Nicholson Jeremy K.,Holmes Elaine

Publisher

Elsevier BV

Subject

Spectroscopy,Process Chemistry and Technology,Computer Science Applications,Software,Analytical Chemistry

Reference27 articles.

1. “Metabonomics”: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data;Nicholson;Xenobiotica,1999

2. Metabonomics: a generic platform for the study of drug toxicity and gene function;Nicholson;Nat. Rev., Drug Discov.,2002

3. Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids;Lindon;Prog. Nucl. Magn. Reson. Spectrosc.,2000

4. The application of pattern recognition methods to the analysis and classification of toxicological data derived from NMR spectroscopy of urine;Gartland;Mol. Pharmacol.,1991

5. Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks;Holmes;Chem. Res. Toxicol.,2001

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