Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol 4 4Abbreviations: MC, mitomycin C; DIC, dicumarol; 2,7-DAM, 2,7-diaminomitosene; and XDH, xanthine dehydrogenase.

Author:

Palom Yolanda,Belcourt Michael F,Tang Li-Qun,Mehta Shilpi S,Sartorelli Alan C,Pritsos Chris A,Pritsos Karen L,Rockwell Sara,Tomasz Maria

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference43 articles.

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3. Enzyme-directed bioreductive drug development revisited;Workman;Oncol Res,1994

4. The mitomycin bioreductive antitumor agents;Tomasz;Pharmacol Ther,1997

5. 2,7-Diaminomitosene, a monofunctional mitomycin derivative, alkylates DNA in the major groove. Structure and base-sequence specificity of the DNA adduct and mechanism of the alkylation;Suresh Kumar;J Am Chem Soc,1996

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