Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-Amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin-6-yl)-(S)-ethyl]-2,5-thienoylamino-l-glutamic acid (AG2034)

Author:

Faessel Hélène M.,Slocum Harry K.,Rustum Youcef M.,Greco William R.

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference53 articles.

1. The contributions of de novo and salvage pathways of nucleotide biosynthesis in normal and malignant cells;Jackson,1981

2. Enzymes of salvage and de novo pathways of synthesis of pyrimidine nucleotides in human colorectal adenocarcinomas;Ahmed;Biochem Pharmacol,1982

3. Enzymology of pyrimidine and carbohydrate metabolism in human colon carcinomas;Denton;Cancer Res,1982

4. AG2034: A novel inhibitor of glycinamide ribonucleotide formyltransferase;Boritzki;Invest New Drugs,1996

5. Antitumor therapeutic index of LY309887 is improved with increased folic acid supplementation in mice maintained on a folate deficient diet;Worzella;Proc Am Assoc Cancer Res,1996

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