Combination effects of platinum drugs and N 1, N 11 diethylnorspermine on spermidine/spermine N 1-acetyltransferase, polyamines and growth inhibition in A2780 human ovarian carcinoma cells and their oxaliplatin and cisplatin-resistant variants

Author:

Tummala Ramakumar,Diegelman Paula,Hector Suzanne,Kramer Debora L.,Clark Kimberly,Zagst Patricia,Fetterly Gerald,Porter Carl W.,Pendyala Lakshmi

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference47 articles.

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2. Bergeron RJ, Merriman RL, Olson SG, Wiegand J, Bender J, Streiff RR, Weimar WR (2000) Metabolism and pharmacokinetics of N1, N11-diethylnorspermine in a Cebus apella primate model. Cancer Res 60:4433–4439

3. Bergeron RJ, Weimar WR, Luchetta G, Streiff RR, Wiegand J, Perrin J, Schreier KM, Porter C, Yao GW, Dimova H (1995) Metabolism and pharmacokinetics of N1, N11-diethylnorspermine. Drug Metab Dispos 23:1117–1125

4. Boyer J, Allen WL, McLean EG, Wilson PM, McCulla A, Moore S, Longley DB, Caldas C, Johnston PG (2006) Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res 66:2765–2777

5. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 52:5115–5118

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