Pharmacokinetic study of Tdp1 inhibitor resulted in a significant increase in antitumor effect in the treatment of Lewis lung carcinoma in mice by its combination with topotecan-Reference-Cited by-同舟云学术

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Pharmacokinetic study of Tdp1 inhibitor resulted in a significant increase in antitumor effect in the treatment of Lewis lung carcinoma in mice by its combination with topotecan

Published:2023-11 Issue: Volume:236 Page:115731
ISSN:0731-7085
Container-title:Journal of Pharmaceutical and Biomedical Analysis
language:en
Short-container-title:Journal of Pharmaceutical and Biomedical Analysis

Author:

Okhina Alina A.,Kornienko Tatyana E.,Rogachev Artem D.,Luzina Olga A.,Popova Nelly A.,Nikolin Valery P.,Zakharenko Alexandra L.,Dyrkheeva Nadezhda S.,Pokrovsky Andrey G.,Salakhutdinov Nariman F.,Lavrik Olga I.

Funder

Ministry of Education and Science of the Russian Federation

Russian Science Foundation

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference34 articles.

1. Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target;Comeaux;Drug Metab. Rev.,2014

2. DNA topoisomerases and their poisoning by anticancer and antibacterial drugs;Pommier;Chem. Biol.,2010

3. Dual DNA topoisomerase 1 and tyrosyl-DNA phosphodiesterase 1 inhibition for improved anticancer activity;Zakharenko;Med. Res. Rev.,2019

4. Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts;Brettrager;Cancer Drug. Resist.,2019

5. Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy;Dexheimer;Anticancer Agents Med. Chem.,2008

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