Development and validation of LC-MS/MS method for estimating the pharmacokinetics, protein binding, and metabolic stability of soluble epoxide hydrolase inhibitor EC5026
Author:
Publisher
Elsevier BV
Subject
Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry
Reference13 articles.
1. Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles;Morisseau;Annu. Rev. Pharmacol. Toxicol.,2005
2. Arachidonic acid cytochrome P450 epoxygenase pathway;Spector;J. Lipid Res.,2009
3. Movement to the clinic of soluble epoxide hydrolase inhibitor EC5026 as an analgesic for neuropathic pain and for use as a nonaddictive opioid alternative;Hammock;J. Med. Chem.,2021
4. Rationally designed multitarget agents against inflammation and pain;Hwang;Curr. Med. Chem.,2013
5. Soluble epoxide hydrolase regulation of lipid mediators limits pain;Wagner;Neurotherapeutics,2020
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