Development of a rapid and sensitive LC–MS/MS assay for the determination of sorafenib in human plasma

Author:

Jain Lokesh,Gardner Erin R.,Venitz Jürgen,Dahut William,Figg William D.

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference7 articles.

1. Sorafenib Blocks the RAF/MEK/ERK Pathway, Inhibits Tumor Angiogenesis, and Induces Tumor Cell Apoptosis in Hepatocellular Carcinoma Model PLC/PRF/5

2. Discovery and development of sorafenib: a multikinase inhibitor for treating cancer

3. The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006

4. M. Zhao, M.A. Rudek, P. He, F.T. Hafnerm, M. Radtke, J.J. Wright, B.D. Smith, W.A. Messersmith, M. Hidalgo, S.D. Baker, J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci., 2006.

5. Guidelines for Industry: Bioanalytical Method Validation, http://www.fda.gov/CDER/GUIDANCE/4252fnl.htm, August 5, 2007.

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