Quantitation of a low level coeluting impurity present in a modified oligonucleotide by both LC–MS and NMR

Author:

Smith Marco,Beck Tony

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference26 articles.

1. Nucleic-acid therapeutics: basic principles and recent applications;Opalinska;Nat. Rev. Drug Discov.,2002

2. The therapeutic potential of antisense-mediated exon skipping;van Ommen;Curr. Opin. Mol. Ther.,2008

3. Purity analysis and impurities determination by AEX-HPLC;Thayer,2011

4. High resolution nucleic acid separations by high performance liquid chromatography;Thayer,1996

5. Detecting low-level synthesis impurities in modified phosphorothioate oligonucleotides using liquid chromatography–high resolution mass spectrometry;Nikcevic;Int. J. Mass Spectrom.,2011

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