A generic approach for the determination of residues of alkylating agents in active pharmaceutical ingredients by in situ derivatization–headspace–gas chromatography–mass spectrometry-Reference-Cited by-同舟云学术

A generic approach for the determination of residues of alkylating agents in active pharmaceutical ingredients by in situ derivatization–headspace–gas chromatography–mass spectrometry

Published:2007-11 Issue:3 Volume:45 Page:472-479
ISSN:0731-7085
Container-title:Journal of Pharmaceutical and Biomedical Analysis
language:en
Short-container-title:Journal of Pharmaceutical and Biomedical Analysis

Author:

Alzaga Roberto,Ryan Robert W.,Taylor-Worth Karen,Lipczynski Andrew M.,Szucs Roman,Sandra Pat

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference34 articles.

1. A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity

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3. Residues of genotoxic alkyl mesylates in mesylate salt drug substances: Real or imaginary problems?

4. Voltammetric Sensor for Chemical Toxicity Using [Ru(bpy)2poly(4-vinylpyridine)10Cl)]+ as Catalyst in Ultrathin Films. DNA Damage from Methylating Agents and an Enzyme-Generated Epoxide

5. Toxicity Screening by Electrochemical Detection of DNA Damage by Metabolites Generated In Situ in Ultrathin DNA−Enzyme Films

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