Rapid discovery of cyclopamine analogs from Fritillaria and Veratrum plants using LC-Q-TOF-MS and LC-QqQ-MS-Reference-Cited by-同舟云学术

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Rapid discovery of cyclopamine analogs from Fritillaria and Veratrum plants using LC-Q-TOF-MS and LC-QqQ-MS

Published:2017-08 Issue: Volume:142 Page:201-209
ISSN:0731-7085
Container-title:Journal of Pharmaceutical and Biomedical Analysis
language:en
Short-container-title:Journal of Pharmaceutical and Biomedical Analysis

Author:

Du Yuan,Zheng Zu-Guo,Yu Yue,Wu Zi-Tian,Liang Dan,Li Ping,Jiang Yan,Li Hui-Jun

Funder

National Natural Science Foundation of China

Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference29 articles.

1. Industrial natural product chemistry for drug discovery and development;Bauer;Nat. Prod. Rep.,2014

2. Chemistry, bioactivity and geographical diversity of steroidal alkaloids from the Liliaceae family;Li;Nat. Prod. Rep.,2006

3. Cyclopamine and hedgehog signaling: chemistry biology, medical perspectives;Heretsch;Angew. Chem. Int. Ed.,2010

4. Cyclopamine: from cyclops lambs to cancer treatment;Lee;J. Agric. Food Chem.,2014

5. I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs;Chen;Nat. Prod. Rep.,2016

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1. Undescribed steroidal alkaloids from the bulbs of Fritillaria ussuriensis Maxim and their anti-inflammatory activities;Phytochemistry;2024-09

2. Integration of untargeted and pseudotargeted metabolomics reveals specific markers for authentication and adulteration detection of Fritillariae Bulbus using tandem mass spectrometry and chemometrics;Journal of Pharmaceutical and Biomedical Analysis;2024-05

3. Hydroxylated cyclopamine analogues from Veratrum californicum and their hedgehog pathway inhibiting activity;Bioorganic & Medicinal Chemistry;2023-04

4. UHPLC-Q-Exactive Orbitrap MS/MS-Based Untargeted Metabolomics and Molecular Networking Reveal the Differential Chemical Constituents of the Bulbs and Flowers of Fritillaria thunbergii;Molecules;2022-10-16

5. Identification of Veratrum Species in Pimacao Based on ITS2 Sequences and Steroidal Alkaloids by a Pseudo-Targeted Metabolomics Method;Frontiers in Plant Science;2022-04-11

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