I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs
Author:
Affiliation:
1. Department of Chemical and Systems Biology
2. Stanford University School of Medicine
3. Stanford
4. USA
5. Department of Developmental Biology
Abstract
Outbreaks of cyclopic lambs during the 1950s led to the discovery of cyclopamine and new anticancer therapies.
Funder
National Institute of General Medical Sciences
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/NP/C5NP00153F
Reference48 articles.
1. Cyclopian-Type Malformation in Lambs
2. Field Studies of Cyclopian Malformations in Sheep
3. TOXICOSIS OF VERATRUM CALIFORNICUM IN EWES AND ITS RELATIONSHIP TO A CONGENITAL DEFORMITY IN LAMBS
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