UHPLC-Orbitrap study of the first phase tacrine in vitro metabolites and related Alzheimer's drug candidates using human liver microsomes

Author:

Novak M.,Svobodova B.,Konecny J.,Kuratkova A.,Nevosadova L.,Prchal L.,Korabecny J.,Lauschke V.M.,Soukup O.,Kučera R.

Funder

Charles University

Ministry of Health of the Czech Republic

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference35 articles.

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3. Tau protein aggregation in Alzheimer’s disease: An attractive target for the development of novel therapeutic agents;Jouanne;Eur. J. Med Chem.,2017

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5. Mechanism of action of memantine;Johnson;Curr. Opin. Pharm.,2006

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