Tacrine First-Phase Biotransformation and Associated Hepatotoxicity: A Possible Way to Avoid Quinone Methide Formation-Reference-Cited by-同舟云学术

Tacrine First-Phase Biotransformation and Associated Hepatotoxicity: A Possible Way to Avoid Quinone Methide Formation

Published:2023-08-25 Issue:9 Volume:18 Page:1993-2002
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Novak Martin¹²,Vajrychova Marie²,Koutsilieri Stefania³,Sismanoglou Despoina-Christina³,Kobrlova Tereza²,Prchal Lukas²,Svobodova Barbora²,Korabecny Jan²^ORCID,Zarybnicky Tomas⁴^ORCID,Raisova-Stuchlikova Lucie⁴,Skalova Lenka⁴,Lauschke Volker M.³⁵⁶^ORCID,Kučera Radim¹,Soukup Ondrej²^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Kralove, Charles University, Heyrovskeho 1203, 50005 Hradec Kralove, Czech Republic

2. Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic

3. Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden

4. Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University, Heyrovskeho 1203, 50005 Hradec Kralove, Czech Republic

5. Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, 70376 Stuttgart, Germany

6. University of Tübingen, 72074 Tübingen, Germany

Funder

Grantov? Agentura Cesk? Republiky

Ministerstvo Zdravotnictv? Cesk? Republiky

Univerzita Karlova v Praze

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.3c00219