HPLC–MS/MS methods for the quantitative analysis of ophthalmic acid in rodent plasma and hepatic cell line culture medium

Author:

Geenen Suzanne,Michopoulos Filippos,Kenna J. Gerry,Kolaja Kyle L.,Westerhoff Hans. V.,Wilson Ian

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference19 articles.

1. Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science;Antoine;Expert Opin. Drug Metab. Toxicol.,2008

2. Idiosyncratic drug hepatotoxicity;Kaplowitz;Nat. Rev. Drug Discov.,2005

3. Genomic and metabolomic advances in the identification of disease and adverse event biomarkers;Mendrick;Biomark. Med.,2009

4. Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism;Mitchell;J. Pharmacol. Exp. Ther.,1973

5. Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxophore;Graham;J. Pharmacol. Exp. Ther.,2008

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