Role of esterase mediated hydrolysis of simvastatin in human and rat blood and its impact on pharmacokinetic profiles of simvastatin and its active metabolite in rat

Author:

Li Ziwei,Zhang Jun,Zhang YufengORCID,Zuo ZhongORCID

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference46 articles.

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2. The emerging role of human esterases;Fukami;Drug Metab. Pharmacok.,2012

3. Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors - similarities and differences;Lennernas;Clin. Pharmacokinet.,1997

4. Carboxylesterase 1-mediated drug-drug interactions between clopidogrel and simvastatin;Wang;Biol. Pharm. Bull.,2015

5. Rabbit serum paraoxonase 3 (PON3) is a high-density lipoprotein-associated lactonase and protects low density lipoprotein against oxidation;Draganov;J. Biol. Chem.,2000

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