Carboxylesterase 1-Mediated Drug–Drug Interactions between Clopidogrel and Simvastatin-Reference-Cited by-同舟云学术

Carboxylesterase 1-Mediated Drug–Drug Interactions between Clopidogrel and Simvastatin

Published:2015 Issue:2 Volume:38 Page:292-297
ISSN:0918-6158
Container-title:Biological & Pharmaceutical Bulletin
language:en
Short-container-title:Biol. Pharm. Bull.

Author:

Wang Xinwen¹²,Zhu Hao-Jie²,Markowitz John Seth³

Affiliation:

1. The Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University

2. Department of Clinical, Social, and Administrative Sciences, University of Michigan

3. Department of Pharmacotherapy and Translational Research, and Center for Pharmacogenomics, University of Florida

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Link

https://www.jstage.jst.go.jp/article/bpb/38/2/38_b14-00679/_pdf

Reference24 articles.

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2. 2) Kazui M, Nishiya Y, Ishizuka T, Hagihara K, Farid NA, Okazaki O, Ikeda T, Kurihara A. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug Metab. Dispos., 38, 92–99 (2010).

3. 3) Zhu HJ, Wang X, Gawronski BE, Brinda BJ, Angiolillo DJ, Markowitz JS. Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation. J. Pharmacol. Exp. Ther., 344, 665–672 (2013).

4. 4) Laizure SC, Herring V, Hu Z, Witbrodt K, Parker RB. The role of human carboxylesterases in drug metabolism: have we overlooked their importance? Pharmacotherapy, 33, 210–222 (2013).

5. 5) Prueksaritanont T, Gorham LM, Ma B, Liu L, Yu X, Zhao JJ, Slaughter DE, Arison BH, Vyas KP. In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s. Drug Metab. Dispos., 25, 1191–1199 (1997).

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