Early rapid identification of in vivo rat metabolites of AN6414, a novel boron-containing PDE4 inhibitor by QTRAP LC/MS/MS to support drug discovery

Author:

Bu Wei,Akama Tsutomu,Chanda Sanjay,Sullivan David,Ciaravino Vic,Jarnagin Kurt,Freund Yvonne,Sanders Virginia,Chen Chiao-Wen,Fan Xiaoqing,Heyman Irwin,Liu Liang

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference11 articles.

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2. Special requirements for metabolite characterization;Cox,2005

3. The mass spectrometer in drug metabolism;Sinz,2002

4. A tiered approach to metabolite characterization studies in support of drug discovery;Cox,2004

5. Evaluation of three state-of-the-art metabolite prediction software packages (Meteror, MetaSite, and StarDrop) through independent and synergistic use;T’jollyn;Drug Metab. Dispos.,2011

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