The contamination of valsartan and other sartans, Part 2: Untargeted screening reveals contamination with amides additionally to known nitrosamine impurities

Author:

Scherf-Clavel Oliver,Kinzig Martina,Besa Axel,Schreiber André,Bidmon Clemens,Abdel-Tawab Mona,Wohlfart Jonas,Sörgel Fritz,Holzgrabe Ulrike

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference20 articles.

1. Valsartan: Charchenbezogener Rückruf valsartanhaltiger Arzneimittel, deren Wirkstoff von dem chinesischen Hersteller Zhejiang Huahai Pharmaceutical produziert wurde. Bundesinstitut für Arzneimittel und Medizinprodukte,2019

2. Noch mehr nitrosamine;Buschmann;DAZ,2019

3. Dimethylamine as the key intermediate generated in situ from dimethylformamide (DMF) for the synthesis of thioamides;Liu;Beilstein J. Org. Chem.,2015

4. On-line HPLC-tandem mass spectrometry analysis of contaminants of L-tryptophan associated with the onset of the eosinophilia-myalgia syndrome;Williamson;Toxicol. Lett.,1997

5. An investigation of the cause of the eosinophilia-myalgia syndrome associated with tryptophan use;Belongia;N. Engl. J. Med.,1990

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