Antimalarial drug discovery: development of inhibitors of dihydrofolate reductase active in drug resistance
Author:
Publisher
Elsevier BV
Subject
Drug Discovery,Pharmacology
Reference29 articles.
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2. Resistance to pyrimethamine/sulfadoxine in Plasmodium falciparum in 12 villages in north east Tanzania and a test of chlorproguanil/dapsone
3. The dihydrofolate reductase-thymidylate synthetase gene in the drug resistance of malaria parasites
4. Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance.
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4. Flexible diaminodihydrotriazine inhibitors of Plasmodium falciparum dihydrofolate reductase: Binding strengths, modes of binding and their antimalarial activities;European Journal of Medicinal Chemistry;2020-06
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