Synthesis of a hexahydropyrimido[1,2-a]azepine-2-carboxamide derivative useful as an HIV integrase inhibitor

Author:

Ferrara Marco,Crescenzi Benedetta,Donghi Monica,Muraglia Ester,Nizi Emanuela,Pesci Silvia,Summa Vincenzo,Gardelli Cristina

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference10 articles.

1. Inhibitors of Strand Transfer That Prevent Integration and Inhibit HIV-1 Replication in Cells

2. Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques

3. Crescenzi, B.; Gardelli, C.; Donghi, M.; Ferrara, M.; Pace, P.; Kinzel, O.; Muraglia, E.; Rowley, L.; Fiore, F.; Gonzalez Paz, O.; Fonsi, M.; Stillmock, K. A.; Witmer, M. V.; Hazuda, D. J.; Summa, V. Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, USA, Sept 10–14, 2006.

4. The synthesis of tetrahydropyridopyrimidones as a new scaffold for HIV-1 integrase inhibitors

5. Synthesis of 5,6-dihydroxy-2-phenyl-4-pyrimidinecarboxylic acid, methyl ester, a corrected structure

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