Enzymatic cyclization of 26- and 27-methylidenesqualene to novel unnatural C31 polyprenoids by squalene:hopene cyclase
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference33 articles.
1. Enzymatic cyclization of squalene and oxidosqualene to sterols and triterpenes
2. Enzyme Mechanisms for Polycyclic Triterpene Formation
3. Squalene–hopene cyclase: catalytic mechanism and substrate recognition
4. Prokaryotic Hopanoids and other Polyterpenoid Sterol Surrogates
5. Mechanism-Based Inhibitors and Other Active-Site Targeted Inhibitors of Oxidosqualene Cyclase and Squalene Cyclase
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1. Squalene-Hopene Cyclase: Mechanistic Insights into the Polycyclization Cascades of Squalene Analogs Bearing Ethyl and Hydroxymethyl Groups at the C-2 and C-23 Positions;Chemistry - A European Journal;2018-07-05
2. Mutated variants of squalene-hopene cyclase: enzymatic syntheses of triterpenes bearing oxygen-bridged monocycles and a new 6,6,6,6,6-fusded pentacyclic scaffold, named neogammacerane, from 2,3-oxidosqualene;Organic & Biomolecular Chemistry;2018
3. β-Amyrin biosynthesis: catalytic mechanism and substrate recognition;Organic & Biomolecular Chemistry;2017
4. Substrate specificity of a novel squalene-hopene cyclase from Zymomonas mobilis;Journal of Molecular Catalysis B: Enzymatic;2012-12
5. Bacterial Squalene Cyclase;Comprehensive Natural Products II;2010
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