Mutated variants of squalene-hopene cyclase: enzymatic syntheses of triterpenes bearing oxygen-bridged monocycles and a new 6,6,6,6,6-fusded pentacyclic scaffold, named neogammacerane, from 2,3-oxidosqualene-Reference-Cited by-同舟云学术

Mutated variants of squalene-hopene cyclase: enzymatic syntheses of triterpenes bearing oxygen-bridged monocycles and a new 6,6,6,6,6-fusded pentacyclic scaffold, named neogammacerane, from 2,3-oxidosqualene

Published:2018 Issue:37 Volume:16 Page:8365-8378
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Fukuda Yoriyuki¹²³⁴⁵,Watanabe Takashi¹²³⁴⁵,Hoshino Tsutomu¹²³⁴⁵^ORCID

Affiliation:

1. Graduate School of Science and Technology and Department of Applied Biological Chemistry

2. Faculty of Agriculture

3. Niigata University

4. Niigata 950-2181

5. Japan

Abstract

First enzymatic syntheses of triterpenes bearing a 7-oxabicyclo[2.2.1]heptane moiety and a novel scaffold, named neogammacerane, by the mutated cyclases.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB02009D

Reference57 articles.

1. Zur Kenntnis der Triterpene. 190. Mitteilung. Eine stereochemische Interpretation der biogenetischen Isoprenregel bei den Triterpenen

2. Enzyme Mechanisms for Polycyclic Triterpene Formation

3. Squalene–hopene cyclase: catalytic mechanism and substrate recognition