An optimised synthesis of SG3376, a non-cleavable antibody-drug conjugate pyrrolobenzodiazepine drug-linker

Author:

Tiberghien Arnaud C.,Gregson Stephen J.,Masterson Luke A.,Levy Jean-Noel,Kemp Gary C.,Adams Lauren R.,Patel Neki V.,Howard Philip W.

Funder

Spirogen

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference20 articles.

1. Strategies and challenges for the next generation of antibody-drug conjugates;Beck;Nat Rev Drug Discov,2017

2. Antibody drug conjugates for cancer therapy;Polakis;Pharmacol Rev,2016

3. SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML;Kung Sutherland;Blood,2013

4. Fathi AT, Erba HP, Lancet JE, et al., Vadastuximab Talirine Plus Hypomethylating Agents: A Well-Tolerated Regimen with High Remission Rate in Frontline Older Patients with Acute Myeloid Leukemia (AML). In ASH 58th Annual Meeting and Exposition: San Diego, 2016; p 591.

5. Synthesis of a C2-aryl-pyrrolo[2,1-c][1,4]benzodiazepine monomer enabling the convergent construction of symmetrical and non-symmetrical dimeric analogs;Kolakowski;Tetrahedron Lett,2015

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