Synthesis of a 5-alkoxypyrido[3,4-d]pyrimidin-4(3H)-one derivative via directed ortho-metallation of a pyridine analogue

Author:

Dishington Allan P.,Johnson Paul D.,Kettle Jason G.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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3. Tyrosine Kinase Inhibitors. 14. Structure−Activity Relationships for Methyl- amino-Substituted Derivatives of 4-[(3-Bromophenyl)amino]-6-(methylamino)- pyrido[3,4-d]pyrimidine (PD 158780), a Potent and Specific Inhibitor of the Tyrosine Kinase Activity of Receptors for the EGF Family of Growth Factors

4. Cockerill, G. S.; Carter, M. C.; Guntrip, S. B.; Smith, K. J. PCT Int. Appl. 1998 WO 9802438

5. Bridges, A. J.; Denny, W. A.; Dobrusin, E. M.; Doherty, A. M.; Fry, D. W.; McNamara, D. J.; Showalter, H. D.; Smail, J. B.; Zhou, H. PCT Int. Appl. 1997 WO 9738983

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