A practical synthesis of LFA-1 inhibitors utilizing CuCl-promoted intramolecular cyclization of thiohydantoins-Reference-Cited by-同舟云学术

A practical synthesis of LFA-1 inhibitors utilizing CuCl-promoted intramolecular cyclization of thiohydantoins

Published:2005-01 Issue:2 Volume:46 Page:273-276
ISSN:0040-4039
Container-title:Tetrahedron Letters
language:en
Short-container-title:Tetrahedron Letters

Author:

Wang Xiao-jun,Zhang Li,Xu Yibo,Krishnamurthy Dhileepkumar,Varsolona Richard,Nummy Laurence,Shen Sherry,Frutos Rogelio P.,Byrne Denis,Chung J.C.,Farina Vittorio,Senanayake Chris H.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference13 articles.

1. Binding Site Elucidation of Hydantoin-Based Antagonists of LFA-1 Using Multidisciplinary Technologies: Evidence for the Allosteric Inhibition of a Protein−Protein Interaction

2. Wu, J.-P.; Kelly, T. A.; Lemieux, R.; Goldberg, D. R.; Emeigh, J. E.; Sorcek, R. J. U.S. Patent WO-2001007440, 2001

3. Self-Regeneration of Stereocenters: A Practical Enantiospecific Synthesis of LFA-1 Antagonist BIRT-377

4. An improved synthesis of N-aryl-hydantoin LFA-1 antagonists via the enantiospecific alkylation of an isobutyraldehyde-derived imidazolidinone template

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