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Mibefradil reduces hepatic glucose output in HepG2 cells via Ca2+/calmodulin-dependent protein kinase II-dependent Akt/forkhead box O1signaling

  • Published:2021-09 Issue: Volume:907 Page:174296
  • ISSN:0014-2999
  • Container-title:European Journal of Pharmacology
  • language:en
  • Short-container-title:European Journal of Pharmacology

Author:

Ying Dai,Mengya Shan,Peilin Li,Lingong Zhao,huan Ma,Jing Xu,Le Zhang,Kebin Zhang,Bin Chen,Jun Yan,Shaodong Guo,Zihui Xu

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Pharmacology

Reference41 articles.

1. Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice;Altomonte;Am. J. Physiol. Endocrinol. Metab.,2003

2. Diagnosis and classification of diabetes mellitus;Diabetes Care,2010

3. Evidence for mechanistic alterations of Ca2+ homeostasis in Type 2 diabetes mellitus;Balasubramanyam;Int. J. Exp. Diabetes Res.,2001

4. PINK1 alleviates palmitate induced insulin resistance in HepG2 cells by suppressing ROS mediated MAPK pathways;Cang;Biochem. Biophys. Res. Commun.,2016

5. FoxO1: mute for a tuned metabolism?;Cheng;Trends Endocrinol. Metabol.,2015

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