The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation-Reference-Cited by-同舟云学术

The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation

Published:2024-03 Issue: Volume:966 Page:176329
ISSN:0014-2999
Container-title:European Journal of Pharmacology
language:en
Short-container-title:European Journal of Pharmacology

Author:

Arias Hugo R.,Rudin Deborah^ORCID,Hines Dustin J.,Contreras April,Gulsevin Alican^ORCID,Manetti Dina^ORCID,Anouar Youssef,De Deurwaerdere Philippe,Meiler Jens^ORCID,Romanelli Maria Novella^ORCID,Liechti Matthias E.,Chagraoui Abdeslam^ORCID

Funder

University of Oklahoma Health Sciences Center

Center for Health Sciences, Oklahoma State University

Università degli Studi di Firenze

Publisher

Elsevier BV

Reference63 articles.

1. (+)-Catharanthine and (-)-18-methoxycoronaridine induce antidepressant-like activity in mice by differently recruiting serotonergic and norepinephrinergic neurotransmission;Arias;Eur. J. Pharmacol.,2023

2. Coronaridine congeners induce sedative and anxiolytic-like activity in naive and stressed/anxious mice by allosteric mechanisms involving increased GABA(A) receptor affinity for GABA;Arias;Eur. J. Pharmacol.,2023

3. Coronaridine congeners potentiate GABA(A) receptors and induce sedative activity in mice in a benzodiazepine-insensitive manner;Arias;Prog. Neuro-Psychopharmacol. Biol. Psychiatry,2020

4. Coronaridine congeners decrease neuropathic pain in mice and inhibit alpha9alpha10 nicotinic acetylcholine receptors and Ca(V)2.2 channels;Arias;Neuropharmacology,2020

5. Hypnotic enhancement of slow-wave sleep increases sleep-associated hormone secretion and reduces sympathetic predominance in healthy humans;Besedovsky;Commun. Biol.,2022

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1. Novel psychoplastogen DM506 reduces cue-induced heroin-seeking and inhibits tonic GABA currents in the Prelimbic Cortex;Neurochemistry International;2024-09

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