A novel harmine derivative, N-(4-(hydroxycarbamoyl)benzyl)-1-(4- methoxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxamide (HBC), as histone deacetylase inhibitor: in vitro antiproliferation, apoptosis induction, cell cycle arrest, and antimetastatic effects

Author:

Miao Jie-Fei,Peng Yan-Fu,Chen Shi,Gao Wei-Jie,Yang Qiu-Xing,Zhu Peng,Guo Jing,Tao Jinhua,Luo Lin,Zhang Yanan,Ling Yong

Funder

Natural Science Foundation of China

Project of “Jiangsu Six Peaks of Talent”

China Pharmaceutical University for the Open Project Program of State Key Laboratory of Natural Medicines

China and Jiangsu Province Postdoctoral Science Foundation

Project of “Jiangsu 333 high-level talents”, Jiangsu Government Scholarship for Overseas Studies

Applied Research Projects of Nantong City

Priority Academic Programs Development of Jiangsu Higher Education Institutions (PAPD)

Publisher

Elsevier BV

Subject

Pharmacology

Reference37 articles.

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2. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A;Butler;J. Am. Chem. Soc.,2010

3. Harmine induces apoptosis in HepG2 cells via mitochondrial signaling pathway;Cao;Hepatobiliary Pancreat. Dis. Int.,2011

4. beta-carboline alkaloids: biochemical and pharmacological functions;Cao;Curr. Med. Chem.,2007

5. A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis;Carvalho;Eur. J. Pharmacol.,2017

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