Prostate Specific Antigen Density as a Predictor of Clinically Significant Prostate Cancer When the Prostate Specific Antigen is in the Diagnostic Gray Zone: Defining the Optimum Cutoff Point Stratified by Race and Body Mass Index

Author:

Aminsharifi Alireza12,Howard Lauren13,Wu Yuan14,De Hoedt Amanda3,Bailey Charlotte3,Freedland Stephen J.35,Polascik Thomas J.13

Affiliation:

1. Duke Cancer Institute, Durham, North Carolina

2. Department of Urology, Shiraz University of Medical Sciences, Shiraz, Iran

3. Durham Veterans Affairs Medical Center, Durham, North Carolina

4. Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina

5. Center for Integrated Research on Cancer and Lifestyle, Cedars-Sinai Medical Center, Los Angeles, California

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Urology

Reference28 articles.

1. Prostate specific antigen: a decade of discovery—what we have learned and where we are going;Polascik;J Urol,1999

2. Loeb S and Eastham J: Diagnosis and staging of prostate cancer. In: Campbell-Walsh Urology, 11th ed. Edited by AJ Wein, LR Kavoussi, AW Partin et al. Philadelphia: Saunders Elsevier 2016; chap 111, pp 2601-2608.

3. Empirical estimates of prostate cancer overdiagnosis by age and prostate-specific antigen;Vickers;BMC Med,2014

4. Utility of digital rectal examination as an adjunct to prostate specific antigen in the detection of clinically significant prostate cancer;Halpern;J Urol,2018

5. Combined value of validated clinical and genomic risk stratification tools for predicting prostate cancer mortality in a high-risk prostatectomy cohort;Cooperberg;Eur Urol,2015

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