1. Medical Oncology and Laboratory of Pre-Clinical Oncology and Developmental Therapeutics, Istituto Di Ricovero e Cura a Carattere Scientifico San Matteo University Hospital Foundation, Pavia, Italy, and Division of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center/Beckman Research Institute, City of Hope Comprehensive Cancer Center (RAF), Duarte, California