Adenoviral Mediated Interferon-α 2b Gene Therapy Suppresses the Pro-Angiogenic Effect of Vascular Endothelial Growth Factor in Superficial Bladder Cancer

Author:

Adam Liana1,Black Peter C.1,Kassouf Wassim1,Eve Beryl1,McConkey David2,Munsell Mark F.3,Benedict William F.4,Dinney Colin P.N.1

Affiliation:

1. Department of Urology, University of Texas M. D. Anderson Cancer Center, Houston, Texas

2. Department of Cancer Biology, University of Texas M. D. Anderson Cancer Center, Houston, Texas

3. Department of Biostatistics and Applied Mathematics, University of Texas M. D. Anderson Cancer Center, Houston, Texas

4. Department of Genitourinary Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Urology

Reference19 articles.

1. Regression of infancy hemangiomas with recombinant IFN-alpha 2b;Garmendia;J Interferon Cytokine Res,2001

2. Inhibition of angiogenesis and vascular tumor growth by interferon-producing cells: a gene therapy approach;Albini;Am J Pathol,2000

3. Inhibition of basic fibroblast growth factor expression, angiogenesis, and growth of human bladder carcinoma in mice by systemic interferon-alpha administration;Dinney;Cancer Res,1998

4. Interferon-alpha-mediated downregulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule;Slaton;Clin Cancer Res,1999

5. A randomized controlled study of intravesical alpha-2b-interferon in carcinoma in situ of the bladder;Glashan;J Urol,1990

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