Rifampicin and Isoniazid Maximal Concentrations are Below Efficacy-associated Thresholds in the Majority of Patients: Time to Increase the Doses?

Author:

Trentalange AliceORCID,Borgogno EnricaORCID,Motta Ilaria,Antonucci Miriam,Pirriatore Veronica,Costa CeciliaORCID,Rossi Giovanni,Barco AmbraORCID,De Nicolò Amedeo,Piccioni Pavilio,D'Avolio Antonio,Bonora Stefano,Di Perri Giovanni,Calcagno Andrea

Funder

Gilead Sciences

Cilag

Meso Scale Diagnostics

Publisher

Elsevier BV

Subject

Pharmacology (medical),Infectious Diseases,Microbiology (medical),General Medicine

Reference41 articles.

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2. Social determinants of therapy failure and multi drug resistance among people with tuberculosis: A review;Di Gennaro;Tuberculosis (Edinb),2017

3. Pharmacokinetics and pharmacogenetics of anti-tubercular drugs: a tool for treatment optimization?;Motta;Expert Opin Drug Metab Toxicol,2018

4. The Role of Therapeutic Drug Monitoring in Mycobacterial Infections;Peloquin;Microbiol Spectr,2017

5. Concentration-dependent Mycobacterium tuberculosis killing and prevention of resistance by rifampin;Gumbo;Antimicrob Agents Chemother,2007

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