A Single Mutation in Framework 2 of the Heavy Variable Domain Improves the Properties of a Diabody and a Related Single-Chain Antibody-Reference-Cited by-同舟云学术

A Single Mutation in Framework 2 of the Heavy Variable Domain Improves the Properties of a Diabody and a Related Single-Chain Antibody

Published:2012-10 Issue:3 Volume:423 Page:337-350
ISSN:0022-2836
Container-title:Journal of Molecular Biology
language:en
Short-container-title:Journal of Molecular Biology

Author:

Rodríguez-Rodríguez Everardo Remi,Ledezma-Candanoza Luis M.,Contreras-Ferrat Luis Gabriel,Olamendi-Portugal Timoteo,Possani Lourival D.,Becerril Baltazar,Riaño-Umbarila Lidia

Funder

Instituto Bioclon S.A. de C.V. (Mexico)

CONACyT

Instituto de Ciencia y Tecnologia del Distrito Federal (Mexico City)

Publisher

Elsevier BV

Subject

Molecular Biology,Structural Biology

Reference39 articles.

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3. Protein engineering of single-chain Fv analogs and fusion proteins;Huston;Methods Enzymol.,1991

4. “Diabodies”: small bivalent and bispecific antibody fragments;Holliger;Proc. Natl Acad. Sci. USA,1993

5. Crystal structure of a diabody, a bivalent antibody fragment;Perisic;Structure,1994

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