Integrating Molecular Models Into CryoEM Heterogeneity Analysis Using Scalable High-resolution Deep Gaussian Mixture Models

Author:

Chen Muyuan,Toader Bogdan,Lederman Roy

Funder

NIMH

NIGMS

Air Force Office of Scientific Research

National Institutes of Health

Publisher

Elsevier BV

Subject

Molecular Biology,Structural Biology

Reference34 articles.

1. CryoDRGN: reconstruction of heterogeneous cryo-EM structures using neural networks;Zhong;Nature Methods,2021

2. Structural Basis for Gating and Activation of RyR1;des Georges;Cell,2016

3. 3D variability analysis: Resolving continuous flexibility and discrete heterogeneity from single particle cryo-EM;Punjani;J. Struct. Biol.,2021

4. Continuously heterogeneous hyper-objects in cryo-EM and 3-D movies of many temporal dimensions;Lederman;arXiv [cs.CV],2017

5. Methods for Cryo-EM Single Particle Reconstruction of Macromolecules having Continuous Heterogeneity;Toader;arXiv [q-bio.BM],2022

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