Kinetic and Structural Characterisation of Escherichia coli Nitroreductase Mutants Showing Improved Efficacy for the Prodrug Substrate CB1954-Reference-Cited by-同舟云学术

Kinetic and Structural Characterisation of Escherichia coli Nitroreductase Mutants Showing Improved Efficacy for the Prodrug Substrate CB1954

Published:2007-04 Issue:2 Volume:368 Page:481-492
ISSN:0022-2836
Container-title:Journal of Molecular Biology
language:en
Short-container-title:Journal of Molecular Biology

Author:

Race Paul R.,Lovering Andrew L.,White Scott A.,Grove Jane I.,Searle Peter F.,Wrighton Christopher W.,Hyde EvaI.

Publisher

Elsevier BV

Subject

Molecular Biology,Structural Biology

Reference28 articles.

1. The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)–I. Purification and properties of a nitroreductase enzyme from Escherichia coli–a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT);Anlezark;Biochem. Pharmacol.,1992

2. The activation of Cb1954 (2,4-dinitro-5-aziridinyl benzamide) in Walker cells Is by bioreduction to a DNA crosslinking agent;Knox;Brit. J. Cancer,1988

3. Nitroreductase: a prodrug-activating enzyme for cancer gene therapy;Searle;Clin. Exp. Pharmacol. Physiol.,2004

4. Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer;Palmer;J. Clin. Oncol.,2004

5. The bystander effect of the nitroreductase CB1954 enzyme prodrug system is due to a cell-permeable metabolite;Bridgewater;Human Gene Therapy,1997

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