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Pushing the Limits of Detection of Weak Binding Using Fragment-Based Drug Discovery: Identification of New Cyclophilin Binders

  • Published:2017-08 Issue:16 Volume:429 Page:2556-2570
  • ISSN:0022-2836
  • Container-title:Journal of Molecular Biology
  • language:en
  • Short-container-title:Journal of Molecular Biology

Author:

Georgiou Charis,McNae Iain,Wear Martin,Ioannidis Harris,Michel Julien,Walkinshaw Malcolm

Funder

European Research Council

Publisher

Elsevier BV

Subject

Molecular Biology,Structural Biology

Reference74 articles.

1. A “rule of three” for fragment-based lead discovery?;Congreve;Drug Discov. Today,2003

2. An improved model for fragment-based lead generation at AstraZeneca;Fuller;Drug Discov. Today,2016

3. Twenty years on: the impact of fragments on drug discovery;Erlanson;Nat. Rev. Drug Discov.,2016

4. Biophysics in drug discovery: impact, challenges and opportunities;Renaud;Nat. Rev. Drug Discov.,2016

5. Current and emerging opportunities for molecular simulations in structure-based drug design;Michel;Phys. Chem. Chem. Phys.,2014
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