Inhibition of β-Catenin Signaling in the Skin Rescues Cutaneous Adipogenesis in Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial of C-82-Reference-Cited by-同舟云学术

Inhibition of β-Catenin Signaling in the Skin Rescues Cutaneous Adipogenesis in Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial of C-82

Published:2017-12 Issue:12 Volume:137 Page:2473-2483
ISSN:0022-202X
Container-title:Journal of Investigative Dermatology
language:en
Short-container-title:Journal of Investigative Dermatology

Author:

Lafyatis Robert,Mantero Julio C.,Gordon Jessica,Kishore Nina,Carns Mary,Dittrich Howard,Spiera Robert,Simms Robert W.,Varga John

Funder

PRISM Biolab

Merck

Bristol Myers Squibb

Biocon

Formation

Genentech/Roche

UCB

Sanofi

Elpidera and Regeneron

National Institutes of Arthritis Musculoskeletal and Skin Disease grants

Scleroderma Center of Research Translation

Department of Defense Award

Publisher

Elsevier BV

Subject

Cell Biology,Dermatology,Molecular Biology,Biochemistry

Reference60 articles.

1. Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis;Akhmetshina;Nat Comm,2012

2. Wnt/beta-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration;Bastakoty;FASEB J,2016

3. Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis;Beyer;Ann Rheum Dis,2013

4. beta-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis;Beyer;Ann Rheum Dis,2012

5. Fibroblast expression of the coactivator p300 governs the intensity of profibrotic response to transforming growth factor beta;Bhattacharyya;Arthritis Rheum,2005

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