The new immunosuppressant, isogarcinol, binds directly to its target enzyme calcineurin, unlike cyclosporin A and tacrolimus-Reference-Cited by-同舟云学术

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The new immunosuppressant, isogarcinol, binds directly to its target enzyme calcineurin, unlike cyclosporin A and tacrolimus

Published:2015-04 Issue: Volume:111 Page:119-124
ISSN:0300-9084
Container-title:Biochimie
language:en
Short-container-title:Biochimie

Author:

Cen Juren,Wang Mengqi,Jiang Guohua,Yin Yanxia,Su Zhenyi,Tong Li,luo Jing,Ma Yipeng,Gao Yadan,Wei Qun

Funder

National Natural Science Foundation of China

National Important Novel Medicine Research Project

International Cooperation Project

Fundamental Research Funds for the Central Universities

Publisher

Elsevier BV

Subject

General Medicine,Biochemistry

Reference34 articles.

1. Calcineurin: form and function;Rusnak;Physiol. Rev.,2000

2. The primary identification of a calcineurin A subunit-like protein in plants;Yang;Biochimie,2009

3. Interaction of calcineurin with substrates and targeting proteins;Li;Trends Cell Biol.,2011

4. Structures of calcineurin and its complexes with immunophilins–immunosuppressants;Ke;Biochem. Biophys. Res. Commun.,2003

5. Crystal structure of calcineurin–cyclophilin–cyclosporin shows common but distinct recognition of immunophilin–drug complexes;Huai;Proc. Natl. Acad. Sci. U.S.A.,2002

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