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Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV

  • Published:2019-07 Issue: Volume:167 Page:110-116
  • ISSN:0166-3542
  • Container-title:Antiviral Research
  • language:en
  • Short-container-title:Antiviral Research

Author:

Kudalkar Shalley N.,Ullah Irfan,Bertoletti Nicole,Mandl Hanna K.,Cisneros José A.,Beloor Jagadish,Chan Albert H.,Quijano Elias,Saltzman W. Mark,Jorgensen William L.,Kumar Priti,Anderson Karen S.

Funder

National Institutes of Health

Yale Macromolecular X-ray Core Facility

DOE

Argonne National Laboratory

National Institute of General Medical Sciences from the National Institutes of Health

NIH-ORIP HEI

Publisher

Elsevier BV

Subject

Virology,Pharmacology

Reference47 articles.

1. PHENIX: a comprehensive Python-based system for macromolecular structure solution;Adams;Acta Crystallogr. Sect. D Biol. Crystallogr.,2010

2. Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility;Bollini;Bioorg. Med. Chem. Lett,2013

3. Overview of nano-drugs characteristics for clinical application: the journey from the entry to the exit point;Bose;J. Nanoparticle Res.,2014

4. [Review of a technic for the estimation of area under the concentration curve in pharmacokinetic analysis];Bourget;Therapie,1993

5. Reducing safety-related drug attrition: the use of in vitro pharmacological profiling;Bowes;Nat. Rev. Drug Discov.,2012
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