Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

Author:

Bowes Joanne,Brown Andrew J.,Hamon Jacques,Jarolimek Wolfgang,Sridhar Arun,Waldron Gareth,Whitebread Steven

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology,General Medicine

Reference104 articles.

1. Stevens, J. L. Future of toxicology — mechanisms of toxicity and drug safety: where do we go from here? Chem. Res. Toxicol. 19, 1393–1401 (2006).

2. Redfern, W. S. et al. Safety pharmacology — a progressive approach. Fundam. Clin. Pharmacol. 16, 161–173 (2002).

3. Smith, D. A. & Schmid, E. F. Drug withdrawals and the lessons within. Curr. Opin. Drug Discov. Devel. 9, 38–46 (2006).

4. European Medicines Agency (EMA). ICH Topic S7A: Safety pharmacology studies for human pharmaceuticals. CPMP/ICH/539/00. EMA website [online] , (2001).

5. European Medicines Agency (EMA). ICH Topic S7B: The nonclinical evaluation of the potential for delayed ventricular repolarization (QT interval prolongation) by human pharmaceuticals. CPMP/ICH/423/02. EMA website [online] , (2005).

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