Mutations close to functional motif IV in HSV-1 UL5 helicase that confer resistance to HSV helicase–primase inhibitors, variously affect virus growth rate and pathogenicity-Reference-Cited by-同舟云学术

Mutations close to functional motif IV in HSV-1 UL5 helicase that confer resistance to HSV helicase–primase inhibitors, variously affect virus growth rate and pathogenicity

Published:2008-10 Issue:1 Volume:80 Page:81-85
ISSN:0166-3542
Container-title:Antiviral Research
language:en
Short-container-title:Antiviral Research

Author:

Biswas Subhajit,Tiley Laurence S.,Zimmermann Holger,Birkmann Alexander,Field Hugh J.

Publisher

Elsevier BV

Subject

Virology,Pharmacology

Reference27 articles.

1. Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapy;Bacon;Clin. Microbiol. Rev.,2003

2. Potent in vivo antiviral activity of the herpes simplex virus primase–helicase inhibitor BAY 57-1293;Betz;Antimicrob. Agents Chemother.,2002

3. The helicase primase inhibitor, BAY 57-1293 shows potent therapeutic antiviral activity superior to famciclovir in BALB/c mice infected with herpes simplex virus type 1;Biswas;Antiviral Res.,2007

4. Single amino acid substitutions in the HSV-1 helicase protein that confer resistance to the helicase–primase inhibitor BAY 57-1293 are associated with increased or decreased virus growth characteristics in tissue culture;Biswas;Arch. Virol.,2007

5. Detection of HSV-1 variants highly resistant to the helicase–primase inhibitor BAY 57-1293 at high frequency in two of ten recent clinical isolates of HSV-1;Biswas;J. Antimicrob. Chemother.,2007

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