Affiliation:
1. Bayer AG, Pharma Research Antiinfectives, Wuppertal, Germany
Abstract
ABSTRACT
BAY 57-1293 belongs to a new class of antiviral compounds and inhibits replication of herpes simplex virus (HSV) type 1 and type 2 in the nanomolar range in vitro by abrogating the enzymatic activity of the viral primase-helicase complex. In various rodent models of HSV infection the antiviral activity of BAY 57-1293 in vivo was found to be superior compared to all compounds currently used to treat HSV infections. The compound shows profound antiviral activity in murine and rat lethal challenge models of disseminated herpes, in a murine zosteriform spread model of cutaneous disease, and in a murine ocular herpes model. It is active in parenteral, oral, and topical formulations. BAY 57-1293 continued to demonstrate efficacy when the onset of treatment was initiated after symptoms of herpetic disease were already apparent.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference24 articles.
1. Bernstein, D. I., M. A. Lovett, and Y. J. Bryson. 1984. The effects of aciclovir on antibody response to herpes simplex virus in primary genital herpetic infections. J. Infect. Dis.150:7-13.
2. Betz, U. A. K., C. A. J. Voβhenrich, K. Rajewsky, and W. Müller. 1996. Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination. Curr. Biol.6:1307-1316.
3. Intravenous Infusion of Cereport Increases Uptake and Efficacy of Acyclovir in Herpes Simplex Virus-Infected Rat Brains
4. Collins, P., and N. M. Oliver. 1985. Comparison of the in vitro and in vivo antiherpes virus activities of the acyclic nucleosides, aciclovir (Zovirax) and 9-[(2-hydroxy-1-hydroxymethylethoxy)methyl]guanine (BWB759U) Antivir. Res.5:145-156.
5. de Clercq, E., and M. Luczac. 1976. Intranasal challenge of mice with herpes simplex virus: an experimental model for the evaluation of the efficacy of antiviral drugs. J. Infect. Dis.133:A226-A236.
Cited by
122 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献